トップページ > 商品情報:製品分類一覧 >02酸化ストレス関連試薬 > L-NAME

      L-NAME
化学名 NG-Nitro-L-arginine methyl ester, hydrochloride
CAS番号 51298-62-5
製品コード N412

 容 量
    税込価格
本体価格
和光コード
1
g
\10,800
 
\10,000
340-07231
 
 
C7H16ClN5O4=269.69
 


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 性 質
L-NAMEは広く用いられているNOS阻害剤の一つで、例えばラットエンドトキシンショックモデルの重篤な血圧低下に対して有効(1 mg/kg i.v.)であることが報告されている。

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参考文献
1) G. A. Gray, C. Schott, Geraldine, Julou-Schaeffer, I. Fleming, J. R. Parratt and J.-C. Stoclet, "The Effect of Inhibitors of the L-Arginine/Nitrtic Oxide Pathway on Endotoxin-induced Loss of Vascular Responsiveness in Anaesthetozed Rats", Br. J. Pharmacol., 1991, 103, 1218.
2) M. G. Belvisi, D. Stretton and P. J. Barnes, "Nitric Oxide as an Endogenous Modulator of Cholinergic Neurotransmission in Guinea-pig Airways", Eur. J. Pharmacol., 1991, 198, 219.
3) P. K. Moore, A. O. Oluyomi, R. C. Babbedge, P. Wallace and S. L. Hart, "L-NG-Nitro Arginine Methyl Ester Exhibits Antinociceptive Activity in the Mouse", Br. J. Pharmacol., 1991, 102, 198.
4) S. M. Gardiner, A. M. Compton, P. A. Kemp and T. Bennett, "Effects of NG-Nitro-L-arginine Methyl Ester or Idomethacin on Differential Regional and Cardiac Haemodynamic Actions of Arginine Vasopressin and Lysine Vasopressin in Conscious Rats", Br. J. Pharmacol., 1991, 102, 65.
5) T. B. Macall, M. Feelisch, R. M. J. Palmer and S. Moncada, "Identification of N'-Iminoethyl-L-ornithine as an Irreversible Inhibitor of Nitric Oxide Synthase in Phagocytic Cells", Br. J. Pharmacol., 1991, 102, 234.
6) P. Kubes, M. Suzuki and D. N. Granger, "Nitric Oxide: An Endogenous Modulator of Leukocyte Adhesion", Proc. Natl. Acad. Sci. USA, 1991, 88, 4651.
7) B. Heinzel, M. John, P. Klatt, E. Bohme and B. Mayer, "Ca2+/Calmodulin-dependent Formation of Hydrogen Peroxide by Brain Nitric Oxide Synthase", Biochem. J., 1992, 281, 627.
8) B. L. Tepperman and B. D. Soper, "Interaction of Nitric Oxide and Salivary Gland Epidermal Growth Factor in the Modulation of Rat Gastric Mucosal Integrity", Br. J. Pharmacol., 1993, 110, 229.
9) K. Kumagai, H. Suzuki, M. Ichikawa, M. Jinbo, M. Murakami, M. Ryuzaki and T. Saruta, "Nitric Oxide Increases Renal Blood Flow by Interactiong with the Synpathetic Nervous System", Hypertension, 1994, 24(2), 220.
10) L. Yu, P. E. Gengaro, M. Niederberger, T. J. Burke and R. W. Schrier, "Nitric Oxide: A Mediator in Rat Tubular Hypoxia/Reoxygenation Injury", Proc. Natl. Acad. Sci. USA, 1994, 91, 1691.
11) C. Baylis, S. Masilamani, G. Losonczy, L. Samsell, P. Harton and K. Engels, "Blood Pressure(BP) and Renal Vasoconstrictor Responses to Acute Blockade of Nitric Oxide : Persisitence of Renal Vasoconstriction Despite Normalization of Bpwith Either Verapamil or Sodium Nitroprusside", J. Pharmacol. Exp. Ther., 1995, 274(3), 1135.
12) T. T. Ma, H. Ischiropoulos and C. A. Brass, "Endotoxin-Stimulated Nitric Oxide Production Increases Injury and Reduces Rat Liver Chemiluminescence During Reperfusion", Gastroenterology, 1995, 108, 463.
13) J. C. Simmons and R. H. Freeman, "L-Argine Analogues Inhibit Aldosterone Secretion in Rats", Am. J. Physiol., 1995, 268(5Pt2), R1137.
14) Hyeyoung Kim and Kyung Hwan Kim, "Effects of a Nitric Oxide Donor and Nitric Oxide Synthase Inhibitors on Acid Secretion of Isolated Rabbit Gastric Glands", Pharmcol., 1996, 53, 331.
15) O. W. Griffith and R. G. Kilbourn, "Nitric Oxide Synthase Inhibitors: Amino Acids", Methods Enzymol., 1996, 268(A), 375.
 
規格
(1) 性状:本品は、白色粉末又は結晶性粉末で水に溶ける。
(2) 水溶状: 試験適合
(3) 薄層クロマトグラフィー: 試験適合
 
溶解例
>10 mg/ml (水)
 
取扱注意
1.危険物第5類 ニトロ化合物 危険等級U, 2.保存方法:冷蔵
 
危険・有害性シンボルマーク(GHS表示)
 


 








 
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